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The Board of Radiation and Isotope Technology (BRIT), a branch of BARC, has
developed p-32, an alternative to holmium (ho-166), a radiopharmaceutical used
in Radiation Synovectomy for rheumatiod arthritis. BRIT suggests use of isotope
p-32 in this treatment and says it can be used in several diagnostic and
therapeutic purposes and has a longer life period and efficacy in comparison to
holmium.
The procedure has been sent to the Radiation Pharmaceutical Committee for its
approval, Dr. N. Sivaprasad, general manager, BRIT told Pharmabiz.
"Widely used compound for Radiation Synovectomy is holmium. But it has
half-life of 1.1 day. This makes it difficult for us to have sufficient time for
preparation of the compound, performing the quality control and quality
assurance tests, packaging, administrating to the patient etc. p-32 has longer
life period as compared to holmium. Thus, it is convenient to use p-32 for
several diagnostic and therapeutic purposes. In the treatment of arthritis it is
as effective as holmium. Once we get the approval, BRIT will synthesize, produce
and market p-32 as a radiopharmaceutical for Rheumatoid Arthritis treatment",
elaborated Dr. Sivaprasad.
Radiation synovectomy is an
effective treatment for patients with rheumatoid
or seronegative arthritis. Result like absorbed does factors versus depth in
model of the rheumatoid joint, that includes regions of bone, articular
cartilage, joint capsule and tissue (synovium) found in all synovial joints are
shown in this treatment. These are factors that are used to estimate absorbed
does and does rate distribution in treated joints.
Realising the importance of readioisotopes in development of new methods for
diagnosis and treatment of cancer, BRIT supplies variety of radiochemicals,
radiopharmaceuticals, sealed sources, radiation sources, labelled compounds and
other allied products to various institutions for the use in medicine, industry,
agriculture and supporting research in Lifesciences and bio-sciences.
(Ref : Chronicle Pharmabiz dated
July 21, 2005)
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